Custom Enzymes and Inhibitors
Selleck Chemical LLC XAV-939 50mg 284028-89-3 NVP-XAV939
XAV-939 (NVP-XAV939) selectively inhibits Wnt/?-catenin-mediated transcription through tankyrase1/2 inhibition with IC50 of 11 nM/4 nM in cell-free assays, regulates axin levels and does not affect CRE, NF-?B or TGF-?. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC XL147 analogue 50mg 956958-53-5 SAR245408
XL147 analogue (SAR245408) is a selective and reversible class I PI3K inhibitor for PI3K?/?/? with IC50 of 39 nM/36 nM/23 nM in cell-free assays, less potent to PI3K?. XL147 analogue induces apoptosis. Phase 1/2. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Zymo Research Corporation Zymolyase (2000 Units Lyophilized) w/ Storage Buffer (500 µl)
The primary yeast lytic activity is -1,3 glucanase and -1,3-glucan laminaripentao-hydrolase. It hydrolyzes glucose polymers at the -1,3-glucan linkages releasing laminaripentaose as the principal product.
Selleck Chemical LLC Aprepitant 25mg 170729-80-3 MK-0869, L-754030
Aprepitant (MK-0869, L-754030) is a potent and selective neurokinin-1 receptor antagonist with IC50 of 0.1 nM. Aprepitant reduces levels of pro-inflammatory cytokines including G-CSF, IL-6, IL-8 and TNF?. Aprepitant inhibits HIV infection of human macrophages. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Saracatinib (AZD0530) 200mg 379231-04-6
Saracatinib (AZD0530) is a potent Src inhibitor with IC50 of 2.7 nM in cell-free assays, and potent to c-Yes, Fyn, Lyn, Blk, Fgr and Lck; less active for Abl and EGFR (L858R and L861Q). Saracatinib induces autophagy. Phase 2/3. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Propylthiouracil 10mg 51-52-5 NSC 6498, NSC 70461
Propylthiouracil (NSC 6498, NSC 70461) is a thyroperoxidase and 5'-deiodinase inhibitor, used to treat hyperthyroidism. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Topotecan HCl 50mg 119413-54-6 NSC609699, Nogitecan HCl, SKFS 104864A
Topotecan HCl (NSC609699, Nogitecan, SKFS 104864A) is a topoisomerase I inhibitor for MCF-7 Luc cells and DU-145 Luc cells with IC50 of 13 nM and 2 nM in cell-free assays, respectively. Topotecan HCl induces autophagy and apoptosis. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Bosutinib (SKI-606) 10mg 380843-75-4
Bosutinib (SKI-606) is a novel, dual Src/Abl inhibitor with IC50 of 1.2 nM and 1 nM in cell-free assays, respectively. Bosutinib also effectively decreases the activity of PI3K/AKT/mTOR, MAPK/ERK and JAK/STAT3 signaling pathways by blocking the phosphorylation levels of p-ERK, p-S6, and p-STAT3. Bosutinib promotes autophagy. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Axitinib 50mg 319460-85-0 AG 013736
Axitinib (AG 013736) is a multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR? and c-Kit with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM in Porcine aorta endothelial cells, respectively. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Sorafenib Tosylate 50mg 475207-59-1 Bay 43-9006
Sorafenib Tosylate (Bay 43-9006) is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell-free assays, respectively. Sorafenib Tosylate inhibits VEGFR-2, VEGFR-3, PDGFR-?, Flt-3 and c-KIT with IC50 of 90 nM, 20 nM, 57 nM, 59 nM and 68 nM, respectively. Sorafenib Tosylate induces autophagy and apoptosis and activates ferroptosis with anti-tumor activity. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Palbociclib (PD0332991) Isethionate 50mg 827022-33-3
Palbociclib (PD0332991) Isethionate is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM in cell-free assays. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc. Phase 3. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Apexbio Technology LLC ICG 001, 847591-62-2, MFCD12196918, 5 mg
MF: C33H32N4O4, MW: 548.63, Solubility: 27.4315mg/mL in DMSO, 35.47 mg/mL in EtOH with ultrasonic,insoluble in H2O. ICG001 is a small molecule inhibitor that targets Wnt/beta-catenin pathway. It inhibits TCF/beta-catenin mediated transcription by competing with beta-catenin for CBP (CREB binding protein) but not p300 binding with an IC50 of 3 uM. It can be used to specifically evaluate the role of CBP/beta-catenin association on WNT signaling and cell physiology.
Apexbio Technology LLC Potent, selective, and ATP-competitive CK2 inhibitor 1009820-21-6. MFCD13184796
Potent, selective, and ATP-competitive CK2 inhibitor 1009820-21-6. MFCD13184796
Reprocell A83-01
A83-01 is a selective inhibitor of the transforming growth factor-beta (TGF-β) type I receptor ALK5, the Activin/Nodal receptor ALK4, and the nodal receptor ALK71. This molecule is more potent than SB431542 in its inhibition of ALK4, 5, and 7, and only weakly inhibits ALK1, 2, 3, and 6. A83-01 inhibits the TGF-β-induced epithelial-to-mesenchymal transition (EMT) via the inhibition of Smad2 phosphorylation2.
